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In the UK, the standard NHS regimen for B12 deficiency without neurological involvement is hydroxocobalamin 1mg IM three times a week for two weeks

The liver can store the vitamin for a long time, so it may take a few years for deficiency and symptoms to develop

In randomized controlled trials in people living with HIV and central fat accumulation, tesamorelin produced clinically meaningful reductions in visceral adipose tissue in a majority of patients and was associated with improvements in liver enzymes when deep abdominal fat decreased

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Mechanism snapshot Positioned within NNMT inhibitor-class research for metabolic and methylation-linked pathways, distinct from NMN replacement biology

GP can find treatment info for those with and without neuro symptoms in their copy of BNF book Chapter 9 Section 1.2 Some UK areas have local B12 treatment guidelines which in some cases are very out of date